Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1499367 | 1.00 | TRPA1 (1.00) | TRPA1ABCB11SIGMAR1HSD11B1MAOB | |
| SCHEMBL4451132 | 1.00 | TRPA1 (1.00) | TRPA1ABCB11SIGMAR1HSD11B1MAOB | |
| SCHEMBL1499368 | 1.00 | TRPA1 (1.00) | TRPA1ABCB11SIGMAR1HSD11B1MAOB | |
| SCHEMBL1499454 | 0.86 | TRPA1 (1.00) | TRPA1ABCB11SIGMAR1HSD11B1MAOB | |
| SCHEMBL4452015 | 0.86 | TRPA1 (1.00) | TRPA1ABCB11SIGMAR1HSD11B1MAOB | |
| SCHEMBL1499452 | 0.86 | TRPA1 (1.00) | TRPA1ABCB11SIGMAR1HSD11B1MAOB | |
| SCHEMBL4450935 | 0.83 | TRPA1 (0.82) | TRPA1ABCB11SIGMAR1HSD11B1MAOB | |
| SCHEMBL4450936 | 0.83 | TRPA1 (0.82) | TRPA1ABCB11SIGMAR1HSD11B1MAOB | |
| SCHEMBL4450932 | 0.83 | TRPA1 (0.82) | TRPA1ABCB11SIGMAR1HSD11B1MAOB | |
| SCHEMBL9004135 | 0.82 | TRPA1 (0.70) | TRPA1MAOBLMNATP53GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176883-A1 | TRPA1 Antagonists | ABBOTT LABORATORIES (US) | 2009-07-09 | — | — | US | claimed |
| US-9108905-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2015-08-18 | — | — | US | disclosed |
| US-20090176883-A1 | TRPA1 Antagonists | ABBOTT LABORATORIES (US) | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176883-A1 | TRPA1 Antagonists | TRPA1, TRPV1, TRPV3 | TRPA1 1/4885ABCB11 861/4885SIGMAR1 303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.