Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.40 |
| ▸ | IAPP | P10997 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450935 | 1.00 | TRPA1 (0.82) | TRPA1LMNAHSD11B1HTR7ABCB11 | |
| SCHEMBL4450936 | 1.00 | TRPA1 (0.82) | TRPA1LMNAHSD11B1HTR7ABCB11 | |
| SCHEMBL4452015 | 0.90 | TRPA1 (1.00) | TRPA1LMNAHSD11B1ABCB11SIGMAR1 | |
| SCHEMBL1499454 | 0.90 | TRPA1 (1.00) | TRPA1LMNAHSD11B1ABCB11SIGMAR1 | |
| SCHEMBL1499452 | 0.90 | TRPA1 (1.00) | TRPA1LMNAHSD11B1ABCB11SIGMAR1 | |
| SCHEMBL4457739 | 0.83 | TRPA1 (1.00) | TRPA1LMNAHSD11B1ABCB11SIGMAR1 | |
| SCHEMBL1499368 | 0.83 | TRPA1 (1.00) | TRPA1LMNAHSD11B1ABCB11SIGMAR1 | |
| SCHEMBL1499367 | 0.83 | TRPA1 (1.00) | TRPA1LMNAHSD11B1ABCB11SIGMAR1 | |
| SCHEMBL4451132 | 0.83 | TRPA1 (1.00) | TRPA1LMNAHSD11B1ABCB11SIGMAR1 | |
| SCHEMBL9004073 | 0.80 | TRPA1 (0.70) | TRPA1LMNAHSD11B1ABCB11SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9108905-B2 | TRPA1 antagonists | ABBVIE INC. (US) | 2015-08-18 | — | — | US | disclosed |
| US-20090176883-A1 | TRPA1 Antagonists | ABBOTT LABORATORIES (US) | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176883-A1 | TRPA1 Antagonists | TRPA1, TRPV1, TRPV3 | TRPA1 1/4885LMNA 2732/4885HSD11B1 3384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.