Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8235738 | 0.89 | KDM4E (0.43) | HDAC1NAMPTADORA3KDM4ELMNA | |
| SCHEMBL2438296 | 0.86 | HDAC1 (0.46) | HDAC1NAMPTADORA3KDM4ELMNA | |
| SCHEMBL8168949 | 0.81 | DGAT1 (0.48) | KMT2AADORA3KDM4ELMNAMAPT | |
| SCHEMBL2436288 | 0.80 | HDAC1 (0.49) | HDAC1NAMPTADORA3KDM4EHDAC10 | |
| SCHEMBL2436833 | 0.80 | ADORA3 (0.39) | HDAC1NAMPTADORA3KDM4ELMNA | |
| SCHEMBL4453120 | 0.79 | HDAC1 (0.52) | HDAC1KMT2AMEN1ADORA3HDAC10 | |
| SCHEMBL3648233 | 0.78 | HDAC1 (0.54) | HDAC1NAMPTADORA3HDAC6 | |
| SCHEMBL12291095 | 0.78 | CNR2 (0.44) | KMT2AMEN1KDM4ELMNAMAPT | |
| SCHEMBL3646356 | 0.77 | NAMPT (0.48) | HDAC1NAMPTKMT2AMEN1HDAC10 | |
| SCHEMBL6963566 | 0.76 | BRD9 (0.48) | KMT2AMEN1KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945617-B1 | HISTONE DEACETYLASE INHIBITORS WITH ARYL-PYRAZOLYL MOTIFS | MERCK SHARP & DOHME (US) | 2012-12-26 | — | — | EP | disclosed |
| US-20090291965-A1 | Histone Deacetylase Inhibitors With Aryl-Pyrazolyl-Motifs | MERCK SHARP & DOHME LLC | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291965-A1 | Histone Deacetylase Inhibitors With Aryl-Pyrazolyl-Motifs | HDAC1, HDAC3, HDAC5 | HDAC1 1/4885NAMPT 578/4885KMT2A 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.