Toluene

Toluene

SCHEMBL4458162

C1COCCOCCOCCOCCOCCO1.Cc1ccccc1

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 7/20 0.65
ACHE P22303 3/20 0.65
TSHR P16473 1/20 0.65
ALOX12 P18054 1/20 0.65
SMN1; SMN2 Q16637 4/20 0.48
CRHBP P24387 2/20 0.48
CRHR2 Q13324 2/20 0.48
HTT P42858 1/20 0.48
HPGD P15428 2/20 0.40
ORAI1 Q96D31 1/20 0.39
ORAI2 Q96SN7 1/20 0.39
ORAI3 Q9BRQ5 1/20 0.39
TRPV6 Q9H1D0 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
GAA P10253 1/20 0.39
POLB P06746 2/20 0.38
NPC1 O15118 1/20 0.38
NFKB1 P19838 1/20 0.38
RAB9A P51151 1/20 0.38
NFKB2 Q00653 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene SCHEMBL10611921 1.00 LMNA (0.65) LMNAACHETSHRALOX12SMN1; SMN2
Toluene SCHEMBL10900065 1.00 LMNA (0.65) LMNAACHETSHRALOX12SMN1; SMN2
Toluene SCHEMBL1573659 1.00 LMNA (0.65) LMNAACHETSHRALOX12SMN1; SMN2
Toluene SCHEMBL11479355 0.97 LMNA (0.61) LMNAACHETSHRALOX12SMN1; SMN2
Toluene SCHEMBL11325304 0.97 LMNA (0.69) LMNAACHETSHRALOX12SMN1; SMN2
Toluene SCHEMBL28230691 0.95 LMNA (0.58) LMNAACHETSHRALOX12SMN1; SMN2
Toluene SCHEMBL7754119 0.92 LMNA (0.55) LMNAACHETSHRALOX12SMN1; SMN2
Toluene SCHEMBL190031 0.89 LMNA (0.58) LMNAACHETSHRALOX12SMN1; SMN2
Toluene SCHEMBL3904025 0.89 LMNA (0.58) LMNAACHETSHRALOX12SMN1; SMN2
Toluene SCHEMBL9640920 0.89 LMNA (0.58) LMNAACHETSHRALOX12SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2010173-A1 COMPOUNDS FOR TREATING PULMONARY HYPERTENSION Bayer HealthCare AG (DE) 2009-01-07 EP disclosed
WO-2007118602-A1 COMPOUNDS FOR TREATING PULMONARY HYPERTENSION BAYER HEALTHCARE AG (DE) 2007-10-25 WO disclosed
EP-1228063-A2 SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY Bayer Corporation (US) 2002-08-07 EP disclosed
WO-2001023375-A2 SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY BAYER CORPORATION (US) 2001-04-05 WO disclosed
US-4254059-A TO PRIMARY AMINES UNDER MILD CONDITIONS USING A GROUP 8 METAL ANIONIC CATALYST COMPOSITION ALLIED CHEMICAL CORPORATION (US) 1981-03-03 US disclosed
US-4232170-A DECARBONYLATION, GROUP 8, METAL HYDRIDE COMPLEXES ALLIED CHEMICAL CORPORATION (US) 1980-11-04 US disclosed