Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | CRHBP | P24387 | 2/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.36 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.36 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.36 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Toluene SCHEMBL190031 | 0.97 | LMNA (0.58) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL9640890 | 0.97 | LMNA (0.58) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL9640920 | 0.97 | LMNA (0.58) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL27542416 | 0.97 | LMNA (0.58) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL27620801 | 0.95 | LMNA (0.55) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL5070511 | 0.95 | LMNA (0.55) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL28199131 | 0.95 | LMNA (0.55) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL10611917 | 0.95 | LMNA (0.55) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL7754116 | 0.95 | LMNA (0.55) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| Toluene SCHEMBL27277002 | 0.95 | LMNA (0.55) | LMNATSHRALOX12ACHESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071420-A1 | INDOLYL-3-GLYOXYLIC ACID DERIVATIVES WITH ANTITUMORAL ACTIVITY | ASTA Medica Aktiengesellschaft (DE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999051224-A1 | INDOLYL-3-GLYOXYLIC ACID DERIVATIVES WITH ANTITUMORAL ACTIVITY | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1999-10-14 | — | — | WO | disclosed |