Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464611 | 0.73 | SMN1; SMN2 (0.47) | IGF1RCYP2C9 | |
| SCHEMBL4459263 | 0.65 | CHRNA7 (0.40) | CYP2A6CYP2C9 | |
| SCHEMBL4472365 | 0.64 | DHFR (0.39) | — | |
| SCHEMBL28854929 | 0.60 | CYP2C9 (0.36) | IGF1RCYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL29454745 | 0.57 | NISCH (0.50) | CYP2C9CYP2C19 | |
| SCHEMBL78566 | 0.57 | NISCH (0.50) | CYP2C9CYP2C19 | |
| SCHEMBL29598957 | 0.57 | NISCH (0.50) | CYP2C9CYP2C19 | |
| SCHEMBL27790030 | 0.57 | NPC1 (0.35) | CYP2E1CYP2A6CYP2C9CYP2B6CYP2C19 | |
| SCHEMBL11836404 | 0.57 | IGF1R (0.40) | IGF1R | |
| SCHEMBL4466158 | 0.56 | VHL (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |