Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.32 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.31 |
| ▸ | ALPI | P09923 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | GRM8 | O00222 | 1/20 | 0.31 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GSR | P00390 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375800 | 0.84 | IDO1 (0.36) | IDO1TDO2PTGS1SLC1A1SLC7A11 | |
| SCHEMBL7200966 | 0.82 | IDO1 (0.36) | IDO1TDO2PTGS1SLC1A1SLC7A11 | |
| SCHEMBL13857821 | 0.82 | SLC1A3 (0.34) | IDO1TDO2SLC1A1GRIK1GRIA1 | |
| SCHEMBL125177 | 0.82 | SLC1A3 (0.34) | IDO1TDO2SLC1A1GRIK1GRIA1 | |
| SCHEMBL598028 | 0.81 | GRIK1 (0.36) | IDO1TDO2GRIK1GRIK2 | |
| SCHEMBL15156025 | 0.81 | IDO1 (0.35) | IDO1TDO2PTGS1SLC1A1SLC7A11 | |
| SCHEMBL1614569 | 0.81 | IDO1 (0.35) | IDO1TDO2PTGS1SLC1A1SLC7A11 | |
| SCHEMBL7241021 | 0.81 | IDO1 (0.35) | IDO1TDO2PTGS1SLC1A1SLC7A11 | |
| SCHEMBL7371563 | 0.78 | PMP22 (0.36) | IDO1TDO2PTGS1SLC7A11SLC7A5 | |
| SCHEMBL5816605 | 0.77 | GRIN2D (0.37) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188048-B2 | Combination therapy | XENOME LIMITED (AU) | 2012-05-29 | — | — | US | disclosed |
| US-20090105129-A1 | Combination therapy | XENOME LTD (AU) | 2009-04-23 | — | — | US | disclosed |
| WO-2008077194-A1 | RECEPTOR AGONISTS | XENOME LTD (AU) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105129-A1 | Combination therapy | OPRL1, SLC6A2, OPRK1 | IDO1 2730/4885TDO2 2633/4885PTGS1 519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.