Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 13/20 | 0.44 |
| ▸ | PPARD | Q03181 | 8/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 7/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450728 | 0.81 | FFAR4 (0.44) | PPARDBACE1PTGDR2PSEN1PSEN2 | |
| SCHEMBL4458626 | 0.79 | BRD4 (0.58) | PPARDBACE1PTGDR2 | |
| SCHEMBL4460094 | 0.79 | BRD4 (0.36) | PPARAPPARDPPARG | |
| SCHEMBL4447366 | 0.79 | BRD4 (0.36) | PPARAPPARDPPARG | |
| SCHEMBL4458627 | 0.78 | BACE1 (0.42) | PPARDBACE1AKR1C3AKR1C2PTGDR2 | |
| SCHEMBL13956446 | 0.77 | FFAR4 (0.44) | PPARDBACE1PTGDR2PSEN1PSEN2 | |
| SCHEMBL1561723 | 0.75 | RXRA (0.55) | — | |
| SCHEMBL13956477 | 0.75 | BACE1 (0.48) | PPARAPPARDBACE1AKR1C3AKR1C2 | |
| SCHEMBL4460417 | 0.74 | PPARG (0.39) | PPARAPPARDPPARG | |
| SCHEMBL13956613 | 0.73 | S1PR5 (0.39) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482484-B2 | Carboxylic acids and derivatives for the treatment of and preventing diabetes and dyslipidaemia | MERCK PATENT GMBH (DE) | 2009-01-27 | — | — | US | disclosed |