Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 5/20 | 0.33 |
| ▸ | PPARD | Q03181 | 4/20 | 0.33 |
| ▸ | PPARG | P37231 | 4/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460094 | 0.86 | BRD4 (0.36) | BRD4TDP1CYP1A2CYP2C9PPARA | |
| SCHEMBL4460417 | 0.81 | PPARG (0.39) | PPARAPPARDPPARGCA2MAPK1 | |
| SCHEMBL4458624 | 0.79 | PPARA (0.44) | PPARAPPARDPPARG | |
| SCHEMBL4447367 | 0.75 | BRD4 (0.64) | BRD4PDE4ACYP1A2 | |
| SCHEMBL4447372 | 0.74 | BRD4 (0.34) | BRD4PPARAPPARDPPARGHSD17B1 | |
| SCHEMBL7974209 | 0.74 | ABCB1 (0.46) | PPARAPPARDPPARG | |
| SCHEMBL21052075 | 0.72 | MAOB (0.54) | PPARDPPARG | |
| SCHEMBL17043171 | 0.71 | BRD4 (0.41) | BRD4MAPK1HSD17B1 | |
| SCHEMBL2304117 | 0.69 | KDM4E (0.44) | HSD17B1 | |
| SCHEMBL4450025 | 0.69 | TSHR (0.36) | PPARAPPARDPPARGCA2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482484-B2 | Carboxylic acids and derivatives for the treatment of and preventing diabetes and dyslipidaemia | MERCK PATENT GMBH (DE) | 2009-01-27 | — | — | US | disclosed |