Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459491 | 0.99 | HRH3 (0.44) | HRH3CYP1A2CYP3A4L3MBTL1L3MBTL3 | |
| SCHEMBL4459061 | 0.74 | HRH3 (0.46) | HRH3CYP1A2CYP3A4L3MBTL1L3MBTL3 | |
| SCHEMBL4459484 | 0.72 | SLC6A3 (0.44) | HRH3CYP1A2CYP3A4L3MBTL1L3MBTL3 | |
| SCHEMBL4281846 | 0.70 | DRD2 (0.33) | — | |
| SCHEMBL2761916 | 0.70 | HRH3 (0.71) | HRH3CYP1A2CYP3A4L3MBTL1L3MBTL3 | |
| SCHEMBL2762024 | 0.70 | HRH3 (0.71) | HRH3CYP1A2CYP3A4L3MBTL1L3MBTL3 | |
| SCHEMBL2911025 | 0.69 | MAPT (0.40) | CYP1A2SLC6A3 | |
| SCHEMBL4462970 | 0.68 | HRH3 (0.44) | HRH3CYP1A2CYP3A4L3MBTL1L3MBTL3 | |
| Hydrochloric Acid SCHEMBL916318 | 0.68 | HRH3 (0.69) | HRH3CYP1A2CYP3A4L3MBTL1L3MBTL3 | |
| Hydrochloric Acid SCHEMBL9034274 | 0.68 | HRH3 (0.69) | HRH3CYP1A2CYP3A4L3MBTL1L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |