SCHEMBL4459254

SCHEMBL4459254

COc1ccc(-c2ccccc2)cc1NN

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.59
MAPT P10636 3/20 0.59
HPGD P15428 3/20 0.59
ALDH1A1 P00352 2/20 0.59
KMT2A Q03164 2/20 0.57
LMNA P02545 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
GAA P10253 1/20 0.56
ACLY P53396 12/20 0.52
MEN1 O00255 1/20 0.51
POLB P06746 1/20 0.51
AGTR1 P30556 1/20 0.50
HDAC1 Q13547 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
ACACB O00763 1/20 0.46
ACACA Q13085 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6130391 0.98 KDM4E (0.57) KDM4EMAPTHPGDALDH1A1KMT2A
SCHEMBL29073121 0.86 KDM4E (0.51) KDM4EMAPTHPGDALDH1A1KMT2A
SCHEMBL2261298 0.84 KDM4E (0.60) KDM4EMAPTHPGDALDH1A1KMT2A
SCHEMBL8078679 0.81 MKNK1 (0.56) KDM4EMAPTACLY
SCHEMBL12230785 0.79 KDM4E (0.68) KDM4EMAPTHPGDALDH1A1KMT2A
SCHEMBL12205828 0.79 KDM4E (0.56) KDM4EMAPTHPGDALDH1A1KMT2A
SCHEMBL3050807 0.79 KMT2A (0.55) KDM4EMAPTHPGDALDH1A1KMT2A
SCHEMBL5457309 0.78 ACLY (0.56) KDM4EMAPTHPGDALDH1A1KMT2A
SCHEMBL5457303 0.78 KDM4E (0.55) KDM4EMAPTHPGDALDH1A1KMT2A
SCHEMBL8069251 0.78 AGTR1 (0.47) KDM4EMAPTALDH1A1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1406863-A4 INSECTICIDAL BIPHENYLTHIOHYDRAZIDES BASF AG (DE) 2005-06-15 EP claimed
EP-1406863-A1 INSECTICIDAL BIPHENYLTHIOHYDRAZIDES BASF AKTIENGESELLSCHAFT (DE) 2004-04-14 EP claimed
WO-2002098841-A1 INSECTICIDAL BIPHENYLTHIOHYDRAZIDES BASF AKTIENGESELLSCHAFT (DE) 2002-12-12 WO claimed
US-6242647-B1 EFFECTIVE AGENTS FOR THE CONTROL OF PESTIFEROUS INSECTS, ESPECIALLY ACARINA AMERICAN CYANAMID COMPANY 2001-06-05 US claimed
CN-110818596-A Semicarbazide compound and preparation and application thereof 合肥锦绣田园化工科技有限公司 2020-02-21 CN disclosed
US-7592374-B2 Insecticidal nitromethylene compounds CROMPTON CORPORATION (US) 2009-09-22 US disclosed
WO-2006094240-A1 INSECTICIDAL, ACARICIDAL, AND FUNGICIDAL NITOMETHYLENE COMPOUNDS CHEMTURA CORPORATION (US) 2006-09-08 WO disclosed
US-20060199850-A1 Insecticidal, acaricidal, and fungicidal nitromethylene compounds WEBER CITY ROAD LLC 2006-09-07 US disclosed
EP-1406863-A4 INSECTICIDAL BIPHENYLTHIOHYDRAZIDES BASF AG (DE) 2005-06-15 EP disclosed
EP-1406863-A1 INSECTICIDAL BIPHENYLTHIOHYDRAZIDES BASF AKTIENGESELLSCHAFT (DE) 2004-04-14 EP disclosed
US-6706895-B1 CHEMICAL INTERMEDIATES FOR BIFENAZATE UNIROYAL CHEMICAL COMPANY, INC. 2004-03-16 US disclosed
WO-2002098841-A1 INSECTICIDAL BIPHENYLTHIOHYDRAZIDES BASF AKTIENGESELLSCHAFT (DE) 2002-12-12 WO disclosed
US-6242647-B1 EFFECTIVE AGENTS FOR THE CONTROL OF PESTIFEROUS INSECTS, ESPECIALLY ACARINA AMERICAN CYANAMID COMPANY 2001-06-05 US disclosed
EP-0641316-B1 INSECTICIDAL PHENYLHYDRAZINE DERIVATIVES UNIROYAL CHEM CO INC (US) 1997-01-22 EP disclosed
US-5536746-A Insecticidal phenylhydrazine derivatives UNIROYAL CHEMICAL COMPANY, INC. (US) 1996-07-16 US disclosed
US-5438123-A Miticides, nematocides UNIROYAL CHEMICAL COMPANY, INC. (US) 1995-08-01 US disclosed
EP-0641316-A1 INSECTICIDAL PHENYLHYDRAZINE DERIVATIVES. UNIROYAL CHEM CO INC (US) 1995-03-08 EP disclosed
US-5367093-A Pesticides UNIROYAL CHEMICAL COMPANY, INC. (US) 1994-11-22 US disclosed
WO-1993010083-A1 INSECTICIDAL PHENYLHYDRAZINE DERIVATIVES UNIROYAL CHEMICAL COMPANY, INC. (US) 1993-05-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060199850-A1 Insecticidal, acaricidal, and fungicidal nitromethylene compounds NIT2, DDT, AADAC KDM4E 921/4885MAPT 3847/4885HPGD 1825/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.