Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 8/20 | 0.57 |
| ▸ | LMNA | P02545 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.57 |
| ▸ | CCR6 | P51684 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11090971 | 0.82 | KDM4E (0.65) | KDM4EHIF1AHTTLMNAALDH1A1 | |
| SCHEMBL9996605 | 0.81 | KDM4E (0.62) | KDM4EHTTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL11086288 | 0.81 | KDM4E (0.60) | KDM4EHIF1AHTTLMNAALDH1A1 | |
| SCHEMBL9996591 | 0.79 | HIF1A (0.60) | KDM4EHIF1AHTTLMNAALDH1A1 | |
| SCHEMBL9996625 | 0.78 | KDM4E (0.57) | KDM4EHIF1AHTTLMNAALDH1A1 | |
| SCHEMBL4459991 | 0.78 | KDM4E (0.70) | KDM4EHIF1AHTTLMNAALDH1A1 | |
| SCHEMBL2315410 | 0.76 | ALDH1A1 (0.55) | KDM4EHIF1AHTTLMNAALDH1A1 | |
| SCHEMBL4457239 | 0.74 | HTT (0.69) | KDM4EHIF1AHTTLMNAALDH1A1 | |
| SCHEMBL4249561 | 0.73 | KDM4E (0.64) | KDM4EHIF1AHTTLMNAALDH1A1 | |
| SCHEMBL7254726 | 0.73 | HIF1A (0.78) | KDM4EHIF1AHTTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350012-B1 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS | UNIV JOHNS HOPKINS (US) | 2017-06-28 | — | — | EP | disclosed |
| US-8729097-B2 | Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and SIRT1, and methods of treating disorders | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-05-20 | — | — | US | disclosed |
| US-20110301163-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301163-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS | SIRT1, SIRT2, SIRT3 | KDM4E 997/4885HIF1A 314/4885HTT 1450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.