Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.50 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203786 | 0.89 | ALDH1A1 (0.60) | MAPTALDH1A1LMNAKCNH2SMN1; SMN2 | |
| SCHEMBL1247295 | 0.88 | MAPT (0.59) | MAPTALDH1A1LMNASMARCA2SMARCA4 | |
| SCHEMBL29745194 | 0.87 | MAPT (0.58) | MAPTALDH1A1LMNASMARCA2SMARCA4 | |
| SCHEMBL3854881 | 0.87 | MAPT (0.58) | MAPTALDH1A1LMNASMARCA2SMARCA4 | |
| SCHEMBL4178856 | 0.87 | MAPT (0.58) | MAPTALDH1A1LMNASMARCA2SMARCA4 | |
| SCHEMBL26351952 | 0.86 | ALDH1A1 (0.57) | MAPTALDH1A1LMNASMARCA2SMARCA4 | |
| SCHEMBL6845367 | 0.85 | MAPT (0.56) | MAPTALDH1A1LMNASMARCA2SMARCA4 | |
| SCHEMBL22835148 | 0.84 | MAPT (0.55) | MAPTALDH1A1LMNAKCNH2MET | |
| SCHEMBL31316587 | 0.83 | ALDH1A1 (0.54) | MAPTALDH1A1LMNAKCNH2GAA | |
| SCHEMBL2382922 | 0.82 | GAA (0.69) | MAPTALDH1A1LMNASMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531542-B2 | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-12 | — | — | US | disclosed |
| US-7531542-B2 | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-12 | — | — | US | disclosed |
| US-7531542-B2 | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-12 | — | — | US | disclosed |
| US-20060264631-A1 | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264631-A1 | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor | GNRHR, GHRHR, LHCGR | MAPT 2825/4885ALDH1A1 4164/4885LMNA 4600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.