Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4492126 | 0.90 | MAPT (0.47) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL4471377 | 0.89 | GAA (0.52) | MAPTGAAALDH1A1KMT2AHPGD | |
| SCHEMBL4465222 | 0.85 | MAPT (0.43) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL4465659 | 0.85 | KMT2A (0.43) | MAPTGAAALDH1A1KMT2AHPGD | |
| SCHEMBL4500342 | 0.85 | MAPT (0.68) | MAPTGAAALDH1A1KMT2AHPGD | |
| SCHEMBL4458183 | 0.81 | GRIN2D (0.38) | MAPTGAAKMT2AMEN1HTT | |
| SCHEMBL4501815 | 0.79 | MEN1 (0.47) | MAPTGAAALDH1A1KMT2AHPGD | |
| SCHEMBL4454534 | 0.78 | GAA (0.48) | MAPTGAAALDH1A1KMT2AHPGD | |
| SCHEMBL4471023 | 0.75 | MEN1 (0.44) | MAPTGAAALDH1A1KMT2AHPGD | |
| SCHEMBL4454976 | 0.74 | KMT2A (0.50) | MAPTALDH1A1KMT2AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010534-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120097-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |