Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4492126 | 0.95 | MAPT (0.47) | MAPTALDH1A1KDM4EGAAAPOBEC3G | |
| SCHEMBL4504602 | 0.89 | MAPT (0.51) | MAPTALDH1A1KDM4EGAAAPOBEC3G | |
| SCHEMBL4471023 | 0.86 | MEN1 (0.44) | MAPTALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL4460460 | 0.85 | MAPT (0.51) | MAPTALDH1A1KDM4EGAAAPOBEC3G | |
| SCHEMBL4458183 | 0.82 | GRIN2D (0.38) | MAPTKDM4EGAAMEN1HTT | |
| SCHEMBL4501815 | 0.81 | MEN1 (0.47) | MAPTALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL4454027 | 0.80 | ALDH1A1 (0.41) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4566658 | 0.78 | CA12 (0.38) | MAPTALDH1A1KDM4EGAAAPOBEC3G | |
| SCHEMBL4454976 | 0.78 | KMT2A (0.50) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4502590 | 0.76 | MAPT (0.39) | MAPTALDH1A1KDM4EGAAAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010534-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120097-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |