Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4501815 | 0.95 | MEN1 (0.47) | MEN1KMT2AALDH1A1DUSP3MAPT | |
| SCHEMBL4454086 | 0.90 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1DUSP3CA12 | |
| SCHEMBL4471377 | 0.87 | GAA (0.52) | MEN1KMT2AALDH1A1DUSP3MAPT | |
| SCHEMBL4566658 | 0.87 | CA12 (0.38) | MEN1KMT2AALDH1A1MAPTCA12 | |
| SCHEMBL4465222 | 0.86 | MAPT (0.43) | MEN1KMT2AALDH1A1MAPTCA12 | |
| SCHEMBL4458183 | 0.82 | GRIN2D (0.38) | MEN1KMT2ADUSP3MAPTCA12 | |
| SCHEMBL4456810 | 0.81 | CA12 (0.41) | MEN1KMT2AALDH1A1MAPTCA12 | |
| SCHEMBL4492126 | 0.81 | MAPT (0.47) | MEN1KMT2AALDH1A1MAPTCA12 | |
| SCHEMBL4454027 | 0.80 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL4499372 | 0.79 | NSD2 (0.39) | MEN1KMT2AALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010534-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120097-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |