Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454976 | 0.91 | KMT2A (0.50) | KMT2AATMALDH1A1MEN1MAPT | |
| SCHEMBL4495436 | 0.86 | ATM (0.55) | KMT2AATMALDH1A1GAAMEN1 | |
| SCHEMBL4460460 | 0.85 | MAPT (0.51) | KMT2AALDH1A1GAAMEN1MAPT | |
| SCHEMBL4471377 | 0.79 | GAA (0.52) | KMT2AALDH1A1GAAMEN1MAPT | |
| SCHEMBL4454534 | 0.78 | GAA (0.48) | KMT2AATMALDH1A1GAAMEN1 | |
| SCHEMBL4457582 | 0.76 | KMT2A (0.55) | KMT2AATMALDH1A1MEN1MAPT | |
| SCHEMBL4492126 | 0.75 | MAPT (0.47) | KMT2AALDH1A1GAAMEN1MAPT | |
| SCHEMBL7084232 | 0.73 | ALDH1A1 (0.49) | KMT2AALDH1A1GAAMEN1MAPT | |
| SCHEMBL9381308 | 0.72 | ATM (0.73) | KMT2AATMALDH1A1GAAMEN1 | |
| SCHEMBL15331728 | 0.72 | KMT2A (0.50) | KMT2AATMALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010534-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120097-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |