Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | MMP14 | P50281 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4469489 | 0.88 | IGF1R (0.38) | IGF1RMMP13 | |
| SCHEMBL4462384 | 0.85 | IGF1R (0.40) | IGF1R | |
| SCHEMBL4461041 | 0.81 | IGF1R (0.42) | IGF1R | |
| SCHEMBL4471687 | 0.77 | IGF1R (0.38) | IGF1R | |
| SCHEMBL4464010 | 0.75 | IGF1R (0.40) | IGF1R | |
| SCHEMBL4469502 | 0.72 | EPHX2 (0.33) | — | |
| SCHEMBL4458966 | 0.69 | IGF1R (0.44) | IGF1R | |
| SCHEMBL4466158 | 0.66 | VHL (0.34) | — | |
| SCHEMBL4462239 | 0.66 | IGF1R (0.44) | IGF1R | |
| SCHEMBL4459152 | 0.61 | IGF1R (0.43) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |