Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7493746 | 0.95 | KDM4E (0.55) | TACR1RIPK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL6092369 | 0.82 | KDM4E (0.58) | TACR1RIPK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL28945745 | 0.82 | KDM4E (0.58) | TACR1RIPK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL8227508 | 0.81 | ALDH1A1 (0.48) | TACR1RIPK1KDM4EMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL12480511 | 0.81 | KDM4E (0.56) | TACR1RIPK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL10775133 | 0.81 | KDM4E (0.56) | TACR1RIPK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL10775129 | 0.81 | KDM4E (0.56) | TACR1RIPK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL4955342 | 0.80 | CHRNB2 (0.55) | RIPK1KDM4EMEN1ALDH1A1HPGD | |
| Benzene SCHEMBL11161088 | 0.80 | CHRNB2 (0.55) | RIPK1KDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL27512084 | 0.80 | CHRNB2 (0.55) | RIPK1KDM4EMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |