Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.48 |
| ▸ | OGFRL1 | Q5TC84 | 4/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | CFB | P00751 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28945745 | 1.00 | KDM4E (0.58) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL12480511 | 0.98 | KDM4E (0.56) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL10775133 | 0.98 | KDM4E (0.56) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL10775129 | 0.98 | KDM4E (0.56) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL7493746 | 0.87 | KDM4E (0.55) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| Phenylpiperazine SCHEMBL27490351 | 0.85 | SIGMAR1 (0.49) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL2789419 | 0.83 | KMT2A (0.52) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL11819504 | 0.83 | ALDH1A1 (0.50) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL18751632 | 0.82 | CHRNB2 (0.56) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL11511516 | 0.82 | FFAR1 (0.52) | MEN1ALDH1A1HPGDKMT2ARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060040984-A1 | Novel piperidine derivatives for use in the treatment of chemokine medicated disease states | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040984-A1 | Novel piperidine derivatives for use in the treatment of chemokine medicated disease states | CCR3, CCR1, CCL11 | KDM4E 4157/4885MEN1 2429/4885ALDH1A1 492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.