Fluocortolone

Fluocortolone

SCHEMBL446143

CCCCCC(=O)O.C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 8/20 0.69
AR P10275 5/20 0.69
ADRA1A P35348 2/20 0.69
CHRM1 P11229 2/20 0.69
ADORA3 P0DMS8 2/20 0.69
SLC6A2 P23975 1/20 0.69
SLC6A3 Q01959 1/20 0.69
KCNH2 Q12809 1/20 0.69
NR1I2 O75469 3/20 0.53
HTR2B P41595 1/20 0.53
CYP3A4 P08684 6/20 0.49
NR3C1 P04150 5/20 0.49
ABCB11 O95342 4/20 0.49
HSD17B10 Q99714 2/20 0.49
LMNA P02545 2/20 0.49
KDM4E B2RXH2 1/20 0.49
CYP2C19 P33261 1/20 0.49
HTR1A P08908 1/20 0.49
ADRA2A P08913 1/20 0.49
HIF1A Q16665 4/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluocortolone SCHEMBL28456329 0.99 PGR (0.68) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL27352188 0.98 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL28207622 0.94 PGR (0.67) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL28473823 0.92 PGR (0.68) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL4644 0.91 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL19327147 0.91 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL3047399 0.91 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL11862489 0.91 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL13902941 0.91 PGR (0.70) PGRARADRA1ACHRM1ADORA3
Fluocortolone SCHEMBL11333890 0.91 PGR (0.70) PGRARADRA1ACHRM1ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2060 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
EP-4301343-B1 PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME TLC BIOPHARMACEUTICALS INC (US) 2025-11-19 EP claimed
EP-4178579-B1 5-AMINO-2,3-DIHYDRO-1,4-PHTHALAZINEDIONE AS GLUCOCORTICOID-SPARING AGENT METRIOPHARM AG (CH) 2025-02-12 EP claimed
EP-3773563-B1 PRODRUGS OF FUSED-BICYCLIC C5AR ANTAGONISTS CHEMOCENTRYX INC (US) 2024-10-16 EP claimed
US-20240156839-A1 PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME TLC BIOPHARMACEUTICALS, INC. 2024-05-16 US claimed
EP-3728203-B1 DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS CHEMOCENTRYX INC (US) 2024-03-13 EP claimed
EP-4301343-A1 PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME TLC Biopharmaceuticals, Inc. (US) 2024-01-10 EP claimed
WO-2023183932-A2 MONOBODIES BINDING TO INTERCELLULAR ADHESION MOLECULE 2 (ICAM-2) NEW YORK UNIVERSITY (US) 2023-09-28 WO claimed
US-20230241060-A1 GLUCOCORTICOID-SPARING AGENT METRIOPHARM AG (CH) 2023-08-03 US claimed
EP-4214183-A1 PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS COMPRISING INHIBITORS OF THE ANDROGEN RECEPTOR AND USES THEREOF Essa Pharma, Inc. (CA) 2023-07-26 EP claimed
WO-2014110454-A1 STABILIZED COMPOSITIONS COMPRISING HYALURONIC ACID CARBYLAN BIOSURGERY, INC. (US) 2014-07-17 WO claimed
WO-2014074823-A1 METHODS AND DEVICES FOR THE TREATMENT OF OCULAR DISEASES IN HUMAN SUBJECTS CLEARSIDE BIOMEDICAL, INC. (US) 2014-05-15 WO claimed
US-20140080795-A1 NRF2 Deficiency Influences Susceptibility to Steroid Resistance via HDAC2 Reduction UNIVERSITY OF ROCHESTER (US) 2014-03-20 US claimed
WO-2013076160-A1 SUSTAINED RELEASE FORMULATIONS USEFUL IN THE TREATMENT OF DISEASES Université Libre de Bruxelles (BE) 2013-05-30 WO claimed
WO-2013033069-A1 HUMAN RHINOVIRUS (HRV) ANTIBODIES THERACLONE SCIENCES, INC. (US) 2013-03-07 WO claimed
US-20130052163-A1 Human Rhinovirus (HRV) Antibodies THERACLONE SCIENCES, INC. (US) 2013-02-28 US claimed
CN-102791273-A Small pyrimidine derivatives and methods of use thereof PROTEOLOGICS LTD 2012-11-21 CN claimed
WO-2012068454-A2 NRF2 DEFICIENCY INFLUENCES SUSCEPTIBILITY TO STEROID RESISTANCE VIA HDAC2 REDUCTION UNIVERSITY OF ROCHESTER (US) 2012-05-24 WO claimed
CN-101420977-A NOGO receptor antagonists BIOGEN IDEC INC (US) 2009-04-29 CN claimed
WO-1997015298-A1 COMBINATION OF LTD, RECEPTOR ANTAGONISTS WITH GLUCOCORTICOSTEROIDS BAYER AKTIENGESELLSCHAFT (DE) 1997-05-01 WO claimed