Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471578 | 0.81 | IGF1R (0.41) | HRH3IGF1R | |
| SCHEMBL4457348 | 0.80 | HRH3 (0.35) | HRH3IGF1R | |
| SCHEMBL1787674 | 0.78 | NOTUM (0.58) | ADORA2AADORA1 | |
| SCHEMBL4459206 | 0.69 | PTPN1 (0.44) | PTPN1IGF1RCXCR1BACE1DRD2 | |
| SCHEMBL21121935 | 0.69 | CXCR1 (0.79) | PTPN1HRH3CXCR1 | |
| SCHEMBL21121342 | 0.69 | CXCR1 (0.79) | PTPN1HRH3CXCR1 | |
| SCHEMBL1789897 | 0.69 | IGF1R (0.59) | IGF1R | |
| SCHEMBL4459340 | 0.68 | PTPN1 (0.43) | PTPN1IGF1RCXCR1DRD2DRD4 | |
| SCHEMBL4907342 | 0.68 | ADORA2A (0.56) | ADORA2AADORA1DRD4ACHEMAOB | |
| SCHEMBL1791868 | 0.67 | NOTUM (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |