Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | SPIN1 | Q9Y657 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471578 | 0.92 | IGF1R (0.41) | HRH3IGF1RSPIN1 | |
| SCHEMBL4457341 | 0.84 | SLC5A7 (0.44) | HRH3IGF1R | |
| SCHEMBL4461468 | 0.80 | PTPN1 (0.47) | HRH3IGF1R | |
| SCHEMBL4463994 | 0.77 | IGF1R (0.31) | IGF1R | |
| SCHEMBL4469774 | 0.72 | NUDT1 (0.49) | — | |
| SCHEMBL1789469 | 0.70 | IGF1R (0.45) | HRH3IGF1R | |
| SCHEMBL4462898 | 0.69 | KDM4E (0.39) | — | |
| SCHEMBL19056415 | 0.64 | LTA4H (0.54) | HRH3LTA4H | |
| SCHEMBL19056693 | 0.64 | DHFR (0.66) | LTA4H | |
| SCHEMBL19056563 | 0.63 | LTA4H (0.53) | HRH3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |