Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.35 |
| ▸ | SPIN1 | Q9Y657 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457348 | 0.92 | HRH3 (0.35) | IGF1RHRH3SPIN1 | |
| SCHEMBL4457341 | 0.86 | SLC5A7 (0.44) | IGF1RHRH3KDM4ESMN1; SMN2 | |
| SCHEMBL4461468 | 0.81 | PTPN1 (0.47) | IGF1RHRH3 | |
| SCHEMBL1789469 | 0.71 | IGF1R (0.45) | IGF1RHRH3 | |
| SCHEMBL1788923 | 0.69 | IGF1R (0.47) | IGF1R | |
| SCHEMBL4463994 | 0.69 | IGF1R (0.31) | IGF1R | |
| SCHEMBL4469774 | 0.63 | NUDT1 (0.49) | KDM4EALDH1A1 | |
| SCHEMBL4463976 | 0.63 | IGF1R (0.45) | IGF1RHRH3 | |
| SCHEMBL19056415 | 0.61 | LTA4H (0.54) | HRH3 | |
| SCHEMBL1715716 | 0.59 | RAB9A (0.39) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |