Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.75 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.69 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | PLG | P00747 | 1/20 | 0.62 |
| ▸ | PLAU | P00749 | 1/20 | 0.62 |
| ▸ | PLAT | P00750 | 1/20 | 0.62 |
| ▸ | RHOC | P08134 | 1/20 | 0.62 |
| ▸ | RHOA | P61586 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060524 | 1.00 | MAPT (0.76) | MAPTPTGS1KCNK3LMNAMEN1 | |
| SCHEMBL4476633 | 0.94 | MAPT (0.86) | MAPTPTGS1KCNK3LMNAMEN1 | |
| SCHEMBL4286068 | 0.90 | MAPT (0.94) | MAPTPTGS1KCNK3LMNAMEN1 | |
| SCHEMBL5345761 | 0.89 | MAPT (0.76) | MAPTPTGS1KCNK3LMNAMEN1 | |
| SCHEMBL6430912 | 0.89 | MAPT (0.81) | MAPTPTGS1KCNK3LMNAMEN1 | |
| SCHEMBL2494871 | 0.87 | KCNK3 (0.81) | MAPTPTGS1KCNK3LMNAMEN1 | |
| SCHEMBL6430910 | 0.87 | MAPT (0.70) | MAPTPTGS1KCNK3LMNAMEN1 | |
| SCHEMBL15094033 | 0.87 | MAPT (0.78) | MAPTPTGS1KCNK3LMNAMEN1 | |
| SCHEMBL4656855 | 0.87 | MAPT (0.78) | MAPTPTGS1KCNK3LMNAMEN1 | |
| SCHEMBL23985152 | 0.87 | RHOC (0.60) | MAPTPTGS1KCNK3LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589101-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2009-09-15 | — | — | US | claimed |
| US-20080287432-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2008-11-20 | — | — | US | claimed |
| EP-1919924-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-05-14 | — | — | EP | claimed |
| WO-2007022268-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-02-22 | — | — | WO | claimed |
| US-7589101-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2009-09-15 | — | — | US | disclosed |
| US-20080287432-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2008-11-20 | — | — | US | disclosed |
| EP-1919924-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007022268-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287432-A1 | Compounds and Compositions as Protein Kinase Inhibitors | AURKC, PTK2B, FRK | MAPT 1523/4885PTGS1 3242/4885KCNK3 924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.