Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | FDPS | P14324 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25179537 | 0.86 | TBXAS1 (0.62) | CYP1A2CYP3A4CYP2C9HDAC2HDAC8 | |
| SCHEMBL12831688 | 0.84 | HDAC2 (0.49) | RECQLCYP1A2CYP3A4CYP2C9CHRNA7 | |
| SCHEMBL3394144 | 0.84 | CYP1A2 (0.51) | RECQLCYP1A2CYP3A4CYP2C9HDAC2 | |
| SCHEMBL29644833 | 0.84 | RECQL (0.66) | RECQLCYP1A2CYP3A4CYP2C9KMT2A | |
| SCHEMBL1815219 | 0.84 | RECQL (0.66) | RECQLCYP1A2CYP3A4CYP2C9KMT2A | |
| SCHEMBL16606311 | 0.81 | CYP1A2 (0.63) | CYP1A2CHRNA7HDAC2HDAC8HDAC6 | |
| SCHEMBL2755854 | 0.81 | RECQL (0.71) | RECQLCYP1A2CYP3A4CYP2C9CHRNA7 | |
| SCHEMBL4344215 | 0.80 | TAAR1 (0.54) | CYP1A2CYP3A4CYP2C9HDAC2NPC1 | |
| SCHEMBL29644853 | 0.79 | SMN1; SMN2 (0.52) | CYP1A2CYP3A4CYP2C9HDAC2HDAC8 | |
| SCHEMBL83186 | 0.78 | RECQL (0.62) | RECQLCYP1A2CYP3A4CYP2C9CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |