Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.39 |
| ▸ | KDM5A | P29375 | 6/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464333 | 0.79 | IGF1R (0.40) | IGF1RKDM5A | |
| SCHEMBL4460989 | 0.73 | FGFR2 (0.34) | IGF1R | |
| SCHEMBL30299324 | 0.60 | HTT (0.39) | HTTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3535759 | 0.58 | HRH3 (0.46) | HTTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL14484041 | 0.58 | HRH3 (0.46) | HTTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL31080045 | 0.58 | IGF1R (0.57) | IGF1RKDM5A | |
| SCHEMBL31080426 | 0.58 | IGF1R (0.57) | IGF1RKDM5A | |
| SCHEMBL25897972 | 0.58 | HTT (0.46) | HTTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL13452625 | 0.57 | ALDH1A1 (0.49) | HTTCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3538827 | 0.57 | PARP1 (0.47) | HTTCHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |