Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459601 | 0.69 | HCAR2 (0.34) | — | |
| SCHEMBL4459720 | 0.61 | HCAR2 (0.33) | — | |
| SCHEMBL4472550 | 0.61 | HCAR2 (0.33) | — | |
| SCHEMBL4473245 | 0.57 | HCAR2 (0.35) | IGF1R | |
| SCHEMBL2173498 | 0.57 | HTR3A (0.33) | HRH4MAPT | |
| SCHEMBL1269500 | 0.56 | — | — | |
| SCHEMBL922677 | 0.55 | HRH4 (0.50) | HRH4 | |
| SCHEMBL605079 | 0.54 | HRH4 (0.66) | HRH4 | |
| SCHEMBL14313774 | 0.52 | ADRA2C (0.41) | HRH4MAPT | |
| SCHEMBL4785792 | 0.52 | JAK2 (0.54) | HRH4JAK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |