Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 4/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384375 | 0.84 | JAK2 (0.70) | JAK2JAK3IKBKBCAMK2DHDAC1 | |
| SCHEMBL28651097 | 0.81 | IKBKB (0.53) | JAK2JAK3IKBKBRETMAPK10 | |
| SCHEMBL14021189 | 0.71 | CAMK2D (0.54) | JAK2JAK3IKBKBMAPK10MAPK8 | |
| SCHEMBL13185630 | 0.71 | IKBKB (0.60) | JAK2JAK3IKBKBMAPK10MAPK8 | |
| SCHEMBL709831 | 0.70 | IKBKB (0.59) | JAK2JAK3IKBKBMAPK10MAPK8 | |
| SCHEMBL1593016 | 0.69 | PRKCD (0.79) | JAK2JAK3IKBKBMAPK10MAPK8 | |
| SCHEMBL8239747 | 0.69 | IKBKB (0.51) | JAK2JAK3IKBKBMAPK10MAPK8 | |
| SCHEMBL7467187 | 0.68 | CDK2 (0.60) | JAK2JAK3IKBKBMAPK10MAPK8 | |
| SCHEMBL710850 | 0.68 | CAMK2D (0.63) | JAK2JAK3IKBKBMAPK10MAPK8 | |
| SCHEMBL12274489 | 0.66 | PIK3CG (0.57) | JAK2IKBKBMAPK8ABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |