Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 2/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1172152 | 0.87 | TAAR1 (0.39) | TSHRTAAR1HTR5A | |
| SCHEMBL1171691 | 0.85 | BACE1 (0.41) | TAAR1 | |
| SCHEMBL1171876 | 0.81 | HTR1A (0.34) | TAAR1HTR5AHTR1AHTR1DHTR2C | |
| SCHEMBL1172224 | 0.74 | BACE1 (0.32) | HTR5A | |
| SCHEMBL15556995 | 0.73 | HTR5A (0.35) | TSHRNUDT1TAAR1HTR5APNMT | |
| SCHEMBL1172120 | 0.72 | BACE1 (0.38) | HTR2AHTR2C | |
| SCHEMBL15488573 | 0.71 | TAAR1 (0.39) | TSHRTAAR1HTR5A | |
| SCHEMBL4468713 | 0.71 | HTT (0.39) | HTR5AHTR1AHTR1DHTR2CHTR7 | |
| SCHEMBL1172201 | 0.71 | BACE1 (0.33) | TSHRHTR5AHTR3A | |
| SCHEMBL4462368 | 0.71 | HTR5A (0.32) | HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |