Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 5/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4469628 | 0.78 | ADORA2A (0.41) | DHFRADORA1 | |
| SCHEMBL30782745 | 0.76 | HRH4 (0.40) | DHFRADORA1 | |
| SCHEMBL29315437 | 0.74 | ADORA1 (0.49) | FGFR1ADORA1 | |
| SCHEMBL30065933 | 0.73 | NPC1 (0.50) | DHFRFGFR1SRC | |
| SCHEMBL3663141 | 0.73 | NPC1 (0.50) | DHFRFGFR1SRC | |
| SCHEMBL14829440 | 0.72 | KMT2A (0.43) | FGFR1 | |
| SCHEMBL15661004 | 0.70 | GAA (0.45) | — | |
| SCHEMBL3933807 | 0.69 | CSF1R (0.50) | DHFRFGFR1 | |
| SCHEMBL15374805 | 0.69 | SMN1; SMN2 (0.37) | — | |
| SCHEMBL15740449 | 0.68 | DHFR (0.43) | DHFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |