Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4259701 | 0.86 | TSHR (0.62) | TSHRCYP3A4GPR35MAPTALDH1A1 | |
| SCHEMBL29864864 | 0.86 | TSHR (0.62) | TSHRCYP3A4GPR35MAPTALDH1A1 | |
| SCHEMBL2960968 | 0.83 | ALDH1A1 (0.61) | TSHRCYP3A4RAB9ANPC1GPR35 | |
| SCHEMBL11189916 | 0.82 | TSHR (0.72) | TSHRCYP3A4RAB9ANPC1GPR35 | |
| SCHEMBL4468465 | 0.81 | MEN1 (0.49) | TSHRCYP3A4RAB9ANPC1MAPT | |
| SCHEMBL12722617 | 0.80 | TSHR (0.55) | TSHRCYP3A4RAB9ANPC1GPR35 | |
| SCHEMBL27930471 | 0.80 | TSHR (0.59) | TSHRCYP3A4GPR35MAPTALDH1A1 | |
| SCHEMBL3538142 | 0.80 | TSHR (0.55) | TSHRCYP3A4RAB9ANPC1GPR35 | |
| SCHEMBL11739674 | 0.79 | TSHR (0.53) | TSHRCYP3A4RAB9ANPC1GPR35 | |
| SCHEMBL2955704 | 0.78 | ALDH1A1 (0.54) | TSHRCYP3A4RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560462-B2 | Compounds useful for inhibiting CHK1 | ICOS CORPORATION (US) | 2009-07-14 | — | — | US | disclosed |
| US-20080214573-A1 | Compounds Useful for Inhibiting Chk1 | ICOS CORPORATION (US) | 2008-09-04 | — | — | US | disclosed |
| CN-101010316-A | Compounds useful for inhibiting CHK1 | ICOS CORP (US) | 2007-08-01 | — | — | CN | disclosed |
| EP-1768977-A2 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | ICOS Corporation (US) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006014359-A2 | COMPOUNDS USEFUL FOR INHIBITING CHK1 | ICOS CORPORATION (US) | 2006-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214573-A1 | Compounds Useful for Inhibiting Chk1 | ORC3, MCM3, CHEK1 | TSHR 1478/4885CYP3A4 3598/4885CYP46A1 3621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.