SCHEMBL4259701

SCHEMBL4259701

Cc1ccc(-c2ccc(C)cc2[N+](=O)[O-])cc1

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.62
CYP3A4 P08684 1/20 0.62
HPRT1 P00492 1/20 0.51
MAPT P10636 3/20 0.50
GPR35 Q9HC97 1/20 0.47
ACHE P22303 2/20 0.47
HSD17B10 Q99714 1/20 0.47
ALDH1A1 P00352 5/20 0.46
TDP1 Q9NUW8 3/20 0.46
MAOA P21397 1/20 0.43
MAOB P27338 1/20 0.43
KAT2B Q92831 2/20 0.43
LMNA P02545 1/20 0.43
AGTR1 P30556 1/20 0.43
KDM4E B2RXH2 1/20 0.42
MEN1 O00255 1/20 0.41
POLB P06746 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29864864 1.00 TSHR (0.62) TSHRCYP3A4HPRT1MAPTGPR35
SCHEMBL14231704 0.91 MAPT (0.57) TSHRCYP3A4HPRT1MAPTGPR35
SCHEMBL27930471 0.90 TSHR (0.59) TSHRCYP3A4HPRT1MAPTGPR35
SCHEMBL12722617 0.90 TSHR (0.55) TSHRCYP3A4HPRT1MAPTGPR35
SCHEMBL2960968 0.89 ALDH1A1 (0.61) TSHRCYP3A4HPRT1MAPTGPR35
SCHEMBL11739674 0.88 TSHR (0.53) TSHRCYP3A4HPRT1MAPTGPR35
SCHEMBL11189916 0.88 TSHR (0.72) TSHRCYP3A4MAPTGPR35ACHE
SCHEMBL28366256 0.87 ACHE (0.57) TSHRCYP3A4HPRT1MAPTGPR35
SCHEMBL2955704 0.87 ALDH1A1 (0.54) TSHRCYP3A4MAPTALDH1A1MAOB
SCHEMBL22696340 0.86 S100A4 (0.49) TSHRCYP3A4HPRT1MAPTGPR35

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240150502-A1 BIPHENYLPHENOL POLYMERIZATION CATALYSTS DOW GLOBAL TECHNOLOGIES LLC (US) 2024-05-09 US disclosed
CN-108440537-B Carbazole derivative, material containing the carbazole derivative, and organic electroluminescent device 石家庄诚志永华显示材料有限公司 2021-04-27 CN disclosed
US-9566265-B2 Carbazole compounds and therapeutic uses of the compounds INCURON, LLC (US) 2017-02-14 US disclosed
US-20150342927-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS INCURON, INC. 2015-12-03 US disclosed
US-20090242876-A1 CARBAZOLE COMPOUNDS KONINKLIJKE PHILIPS ELECTRONICS, N.V. (NL) 2009-10-01 US disclosed
US-20090242876-A1 CARBAZOLE COMPOUNDS KONINKLIJKE PHILIPS ELECTRONICS, N.V. (NL) 2009-10-01 US disclosed
US-20090242876-A1 CARBAZOLE COMPOUNDS KONINKLIJKE PHILIPS ELECTRONICS, N.V. (NL) 2009-10-01 US disclosed
EP-1838671-B1 9,9'- AND 2,2'-SUBSTITUTED 3,3'-BICARBAZOLYL DERIVATIVES FOR USE IN SEMICONDUCTING MATERIALS AS A HOST MATRIX FOR PHOSPHORESCENT EMITTERS KONINKL PHILIPS ELECTRONICS NV (NL) 2008-06-04 EP disclosed
EP-1838671-A2 9,9'- AND 2,2'-SUBSTITUTED 3,3'-BICARBAZOLYL DERIVATIVES FOR USE IN SEMICONDUCTING MATERIALS AS A HOST MATRIX FOR PHOSPHORESCENT EMITTERS Koninklijke Philips Electronics N.V. (NL) 2007-10-03 EP disclosed
WO-2006061759-A2 9 , 9 ' - AND 2 , 2 ' -SUBSTITUTED 3 , 3 ' -BICARBAZOLYL DERIVATIVES FOR USE IN SEMICONDUCTING MATERIALS AS A HOST MATRIX FOR PHOSPHORESCENT EMITTERS KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) 2006-06-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090242876-A1 CARBAZOLE COMPOUNDS CCNI, IL33, PAICS TSHR 4594/4885CYP3A4 97/4885HPRT1 110/4885
US-20150342927-A1 CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS MALT1, PAICS, BCL9 TSHR 3422/4885CYP3A4 72/4885HPRT1 71/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.