Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD5 | P21918 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485184 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4ETDP1MEN1KMT2A | |
| SCHEMBL16979837 | 0.84 | SMN1; SMN2 (0.69) | SMN1; SMN2KDM4EL3MBTL1TDP1MEN1 | |
| SCHEMBL15508836 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2KDM4EL3MBTL1TDP1MEN1 | |
| SCHEMBL14970510 | 0.82 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EL3MBTL1TDP1MEN1 | |
| SCHEMBL14970722 | 0.82 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EMEN1KMT2ATSHR | |
| SCHEMBL4477326 | 0.81 | LTA4H (0.62) | SMN1; SMN2KDM4ETDP1MCHR1LTA4H | |
| SCHEMBL14970724 | 0.81 | LTA4H (0.53) | SMN1; SMN2KDM4EMCHR1LTA4HPOLB | |
| Hydrochloric Acid SCHEMBL14966443 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EMEN1KMT2ATSHR | |
| SCHEMBL4524330 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4ETDP1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL14966770 | 0.80 | LTA4H (0.52) | SMN1; SMN2KDM4ELTA4HPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592358-B2 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |
| US-20050234101-A1 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234101-A1 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | MCHR1, GPR119, MCHR2 | SMN1; SMN2 2309/4885KDM4E 2256/4885L3MBTL1 1955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.