Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169310 | 0.82 | P2RX7 (0.67) | P2RX7ABCB11HIF1APOLBNPC1 | |
| SCHEMBL2168393 | 0.82 | P2RX7 (1.00) | P2RX7ABCB11HIF1AKMT2A | |
| SCHEMBL4465535 | 0.82 | P2RX7 (0.69) | P2RX7ABCB11HIF1AROCK2ROCK1 | |
| SCHEMBL4471577 | 0.80 | P2RX7 (0.69) | P2RX7ABCB11HIF1APOLBNPC1 | |
| SCHEMBL4472433 | 0.77 | P2RX7 (0.72) | P2RX7ABCB11HIF1APOLBKDM4E | |
| SCHEMBL5118090 | 0.76 | P2RX7 (0.67) | P2RX7ABCB11HIF1APOLBNPC1 | |
| SCHEMBL4482089 | 0.75 | P2RX7 (1.00) | P2RX7ABCB11HIF1AROCK2ROCK1 | |
| SCHEMBL14609832 | 0.74 | P2RX7 (0.71) | P2RX7ABCB11HIF1APOLBKDM4E | |
| SCHEMBL4470885 | 0.74 | P2RX7 (0.62) | P2RX7ABCB11HIF1ATP53 | |
| SCHEMBL5111555 | 0.74 | P2RX7 (0.66) | P2RX7ABCB11HIF1APOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553972-B2 | Benzamide inhibitors of the P2X7 receptor | PFIZER, INC. (US) | 2009-06-30 | — | — | US | claimed |