Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.65 |
| ▸ | CNR2 | P34972 | 7/20 | 0.52 |
| ▸ | CNR1 | P21554 | 6/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11850424 | 0.87 | CNR1 (0.69) | TPMTCNR2CNR1TSHRSRD5A2 | |
| SCHEMBL16864334 | 0.85 | TPMT (0.50) | TPMTCNR2CNR1TTRTSHR | |
| SCHEMBL9541835 | 0.85 | CNR2 (0.70) | TPMTCNR2CNR1RXRARXRB | |
| SCHEMBL9360597 | 0.83 | MAPK1 (0.72) | TPMTCNR2CNR1HCAR1SRD5A2 | |
| SCHEMBL11848876 | 0.83 | TPMT (0.48) | TPMTCNR2CNR1TTRHCAR1 | |
| SCHEMBL8434278 | 0.83 | SRD5A2 (0.72) | TPMTCNR2CNR1TSHRHCAR1 | |
| SCHEMBL7189753 | 0.82 | CYP3A4 (0.55) | TPMTCNR2CNR1TTRHCAR1 | |
| SCHEMBL15006713 | 0.82 | CNR2 (0.53) | TPMTCNR2CNR1TTRRXRA | |
| SCHEMBL6651963 | 0.82 | CNR1 (0.53) | TPMTCNR2CNR1RXRARXRB | |
| SCHEMBL7807167 | 0.82 | LTA4H (0.53) | TPMTCNR2CNR1TTRTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104364239-A | New diazaspirocycloalkane and azaspirocycloalkane | HOFFMANN LA ROCHE | 2015-02-18 | — | — | CN | claimed |
| CN-105566089-B | The method for being used to prepare 3- trifluoromethyl chalcones | 杜邦公司 | 2019-07-02 | — | — | CN | disclosed |
| CN-104364239-B | Diaza spiro cycloalkane and azaspiro alkane | 霍夫曼-拉罗奇有限公司 | 2017-08-25 | — | — | CN | disclosed |
| CN-104364239-A | New diazaspirocycloalkane and azaspirocycloalkane | HOFFMANN LA ROCHE | 2015-02-18 | — | — | CN | disclosed |
| US-7576088-B2 | Benzodioxole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-08-18 | — | — | US | disclosed |
| EP-1532132-B1 | NOVEL BENZODIOXOLES | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | disclosed |
| US-20050143373-A1 | Benzodioxole derivatives | ALANINE ALEXANDER (FR) | 2005-06-30 | — | — | US | disclosed |
| US-6900227-B2 | Benzodioxole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2005-05-31 | — | — | US | disclosed |
| EP-1532132-A1 | NOVEL BENZODIOXOLES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-05-25 | — | — | EP | disclosed |
| US-20040142922-A1 | Benzodioxole derivatives | HOFFMANN-LA ROCHE INC. | 2004-07-22 | — | — | US | disclosed |
| WO-2004013120-A1 | NOVEL BENZODIOXOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143373-A1 | Benzodioxole derivatives | CNR2, CNR1, GPR119 | TPMT 2228/4885CNR2 1/4885CNR1 2/4885 |
| US-20040142922-A1 | Benzodioxole derivatives | CNR1, CNR2, GPR119 | TPMT 2603/4885CNR2 2/4885CNR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.