SCHEMBL446551

SCHEMBL446551

CCCCCCCCCCCCCC(CCCCCCCCCCCC)NC(=O)C(N)C(N)C(=O)[C@@H](N)CCCNC(=N)N

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GNAI3 P08754 1/20 0.49
GNAO1 P09471 1/20 0.49
GNAI1 P63096 1/20 0.49
DPP7 Q9UHL4 4/20 0.48
RRM1 P23921 1/20 0.45
NOD1 Q9Y239 2/20 0.40
NPY4R P50391 7/20 0.39
NPY1R P25929 5/20 0.39
NPY2R P49146 4/20 0.39
NPY5R Q15761 4/20 0.39
SIRT6 Q8N6T7 1/20 0.38
SIRT1 Q96EB6 1/20 0.38
DPP8 Q6V1X1 2/20 0.36
DPP9 Q86TI2 2/20 0.36
DPP4 P27487 1/20 0.36
SLC15A1 P46059 1/20 0.36
S1PR2 O95136 2/20 0.36
S1PR1 P21453 2/20 0.36
S1PR3 Q99500 2/20 0.36
S1PR5 Q9H228 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2460422 0.99 GNAI3 (0.48) GNAI3GNAO1GNAI1DPP7RRM1
SCHEMBL14627405 0.90 GNAI3 (0.51) GNAI3GNAO1GNAI1DPP7RRM1
Hydrochloric Acid SCHEMBL446543 0.89 GNAI3 (0.50) GNAI3GNAO1GNAI1DPP7RRM1
Hydrochloric Acid SCHEMBL5540410 0.87 GNAI3 (0.52) GNAI3GNAO1GNAI1DPP7RRM1
SCHEMBL16209914 0.84 GNAI3 (0.57) GNAI3GNAO1GNAI1DPP7RRM1
SCHEMBL25670816 0.81 GNAI3 (0.50) GNAI3GNAO1GNAI1DPP7RRM1
SCHEMBL24420660 0.81 DPP7 (0.73) GNAI3GNAO1GNAI1DPP7RRM1
SCHEMBL27115127 0.81 DPP7 (0.73) GNAI3GNAO1GNAI1DPP7RRM1
SCHEMBL18868846 0.80 DPP7 (0.51) GNAI3GNAO1GNAI1DPP7RRM1
SCHEMBL18868735 0.80 GNAI3 (0.49) GNAI3GNAO1GNAI1DPP7RRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1771206-B1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS GMBH (DE) 2018-04-11 EP disclosed
US-20170036990-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2017-02-09 US disclosed
US-9486538-B2 Lipids, lipid complexes and use thereof SILENCE THERAPEUTICS GMBH (DE) 2016-11-08 US disclosed
US-9387262-B2 Coated lipid complexes and their use SILENCE THERAPEUTICS GMBH (DE) 2016-07-12 US disclosed
EP-2992902-A1 LIPID COMPLEXES COATED WITH PEG AND THEIR USES Silence Therapeutics GmbH (DE) 2016-03-09 EP disclosed
US-20150359906-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2015-12-17 US disclosed
US-9125820-B2 Lipids, lipid complexes and use thereof SILENCE THERAPEUTICS GMBH (DE) 2015-09-08 US disclosed
EP-1830888-B1 LIPID COMPLEXES COATED WITH PEG AND THEIR USE SILENCE THERAPEUTICS GMBH (DE) 2015-08-05 EP disclosed
US-20150031752-A1 COATED LIPID COMPLEXES AND THEIR USE SILENCE THERAPEUTICS AG (DE) 2015-01-29 US disclosed
US-20140329885-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS GMBH (DE) 2014-11-06 US disclosed
US-8735453-B2 Lipids, lipid complexes and use thereof SILENCE THERAPEUTICS GMBH (DE) 2014-05-27 US disclosed
US-20130165381-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2013-06-27 US disclosed
CN-101287497-B Lipid complexes coated with peg and their use SILENCE THERAPEUTICS AG 2013-03-06 CN disclosed
US-8357722-B2 Lipids, lipid complexes and use thereof Silence Therpeutics AG (DE) 2013-01-22 US disclosed
US-20120065138-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2012-03-15 US disclosed
US-20110294871-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2011-12-01 US disclosed
US-8017804-B2 Lipids, lipid complexes and use thereof SILENCE THERAPEUTICS AG (DE) 2011-09-13 US disclosed
US-20100062967-A1 COATED LIPID COMPLEXES AND THEIR USE SILENCE THERAPEUTICS AG (DE) 2010-03-11 US disclosed
US-20080274116-A1 Lipids, Lipid Complexes and Use Thereof SILENCE THERAPEUTICS AG (DE) 2008-11-06 US disclosed
CN-101287497-A Lipid complexes coated with peg and their use SILENCE THERAPEUTICS AG (DE) 2008-10-15 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120065138-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, SGMS1 GNAI3 2142/4885GNAO1 3352/4885GNAI1 2328/4885
US-20110294871-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, SGMS1 GNAI3 2142/4885GNAO1 3352/4885GNAI1 2328/4885
US-20130165381-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, LIPC GNAI3 2535/4885GNAO1 3315/4885GNAI1 2550/4885
US-20100062967-A1 COATED LIPID COMPLEXES AND THEIR USE HDLBP, NR1H3, CETP GNAI3 2209/4885GNAO1 3309/4885GNAI1 1991/4885
US-20170036990-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, LIPC GNAI3 2535/4885GNAO1 3315/4885GNAI1 2550/4885
US-20150359906-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, LIPC GNAI3 2535/4885GNAO1 3315/4885GNAI1 2550/4885
US-20150031752-A1 COATED LIPID COMPLEXES AND THEIR USE HDLBP, NR1H3, CETP GNAI3 2209/4885GNAO1 3309/4885GNAI1 1991/4885
US-20080274116-A1 Lipids, Lipid Complexes and Use Thereof MGLL, LIPA, SGMS1 GNAI3 1929/4885GNAO1 3173/4885GNAI1 2103/4885
US-20140329885-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, LIPC GNAI3 2535/4885GNAO1 3315/4885GNAI1 2550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.