Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Oxyquinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.78 |
| ▸ | TSHR | P16473 | 2/20 | 0.78 |
| ▸ | METAP2 | P50579 | 2/20 | 0.78 |
| ▸ | METAP1 | P53582 | 2/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.78 |
| ▸ | COMT | P21964 | 1/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.71 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KDM4A | O75164 | 2/20 | 0.49 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxyquinoline SCHEMBL2867503 | 1.00 | MMP2 (0.78) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL15568316 | 0.98 | MMP2 (0.75) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL5965842 | 0.94 | MMP2 (0.81) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL27553390 | 0.93 | MMP2 (0.78) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL28459062 | 0.92 | MMP2 (0.84) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL866498 | 0.91 | MMP2 (0.75) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL28315442 | 0.91 | MMP2 (0.81) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL28042473 | 0.91 | MMP2 (0.81) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL27477171 | 0.91 | MMP2 (0.81) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL28191778 | 0.90 | TSHR (0.95) | MMP2TSHRMETAP2METAP1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | claimed |
| US-4225679-A | Floral foam product and method of producing the same which incorporates a flower preservative and a bacteriocide | PENNOCK, VILLAMIL AND PILATO INC. (US) | 1980-09-30 | — | — | US | claimed |
| CN-115128899-A | Photosensitive resin composition with improved system hue stability | 常州正洁智造科技有限公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-111752091-B | Application of HABI mixed photoinitiator in UVLED photocuring | 常州正洁智造科技有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-112835261-B | EO/PO modified 9-phenylacridine photosensitizer and application thereof | 常州强力电子新材料股份有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-114326309-A | Photosensitive resin composition and application thereof | 常州正洁智造科技有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-113929624-A | Pyrazoline compound, photosensitive resin composition and patterning method | 常州强力电子新材料股份有限公司 | 2022-01-14 | — | — | CN | disclosed |
| CN-113527207-A | Ethoxy/propoxy modified pyrazoline organic matter, application thereof, photocuring composition and photoresist | 常州强力电子新材料股份有限公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-110028264-A | A kind of concrete waterproofer | 张郁文 | 2019-07-19 | — | — | CN | disclosed |
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | disclosed |
| US-4659683-A | DISSOLVING IN NITRIC ACID OR AQUA REGIA, NEUTRALIZATION OF THE SOLUTION, THEN PRECIPITATION OF IMPURITIES | BASF AKTIENGESELLSCHAFT (DE) | 1987-04-21 | — | — | US | disclosed |