Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxyquinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.84 |
| ▸ | TSHR | P16473 | 2/20 | 0.84 |
| ▸ | METAP2 | P50579 | 2/20 | 0.84 |
| ▸ | METAP1 | P53582 | 2/20 | 0.84 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.84 |
| ▸ | COMT | P21964 | 1/20 | 0.84 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.84 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.76 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxyquinoline SCHEMBL28042473 | 0.98 | MMP2 (0.81) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL28315442 | 0.98 | MMP2 (0.81) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL27477171 | 0.94 | MMP2 (0.81) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL28191778 | 0.94 | TSHR (0.95) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL2867503 | 0.92 | MMP2 (0.78) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL4465896 | 0.92 | MMP2 (0.78) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL29716519 | 0.92 | TSHR (1.00) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL29365411 | 0.92 | TSHR (1.00) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL37189 | 0.92 | TSHR (1.00) | MMP2TSHRMETAP2METAP1CHRM1 | |
| Oxyquinoline SCHEMBL253313 | 0.92 | TSHR (1.00) | MMP2TSHRMETAP2METAP1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111727212-B | Resin modifier, resin composition, molded article, and molded article | 三洋化成工业株式会社 | 2022-09-16 | — | — | CN | disclosed |
| CN-113614122-A | Resin modifier | 三洋化成工业株式会社 | 2021-11-05 | — | — | CN | disclosed |
| CN-111727212-A | Resin modifier, resin composition, molded article, and molded article | 三洋化成工业株式会社 | 2020-09-29 | — | — | CN | disclosed |