Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19308440 | 0.84 | TDP1 (0.55) | P2RX7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL14920768 | 0.84 | CHRNB2 (0.51) | P2RX7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL2685376 | 0.82 | CHRNB2 (0.47) | P2RX7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1433052 | 0.82 | P2RX7 (0.47) | P2RX7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL6361625 | 0.82 | SMN1; SMN2 (0.47) | P2RX7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5262945 | 0.79 | CHRNB2 (0.50) | P2RX7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL31579540 | 0.79 | CHRNB2 (0.50) | P2RX7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL19177369 | 0.79 | RAB9A (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4EPHX2 | |
| SCHEMBL20924813 | 0.79 | CHRNB2 (0.44) | P2RX7CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL19116526 | 0.78 | SMN1; SMN2 (0.57) | P2RX7CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |