SCHEMBL4466196

SCHEMBL4466196

COc1ccc(C[C@H](NC(=O)c2ccco2)C(=O)O)cc1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.59
FPR2 P25090 1/20 0.59
KMT2A Q03164 2/20 0.59
TSHR P16473 1/20 0.57
CTSL P07711 1/20 0.57
CA2 P00918 1/20 0.57
ALDH1A1 P00352 1/20 0.54
RAB9A P51151 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
PTPN1 P18031 1/20 0.53
ALB P02768 1/20 0.53
IL2 P60568 1/20 0.53
MEN1 O00255 1/20 0.52
ACACB O00763 1/20 0.52
LDHA P00338 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4466200 1.00 NPC1 (0.59) NPC1FPR2KMT2ATSHRCTSL
SCHEMBL840332 0.87 ACACB (0.54) NPC1KMT2ATSHRCTSLALDH1A1
SCHEMBL4264477 0.87 CTSL (0.67) KMT2ATSHRCTSLCA2ALDH1A1
SCHEMBL4267852 0.87 CTSL (0.67) KMT2ATSHRCTSLCA2ALDH1A1
SCHEMBL4264475 0.87 CTSL (0.67) KMT2ATSHRCTSLCA2ALDH1A1
SCHEMBL12016785 0.84 CTSL (0.58) TSHRCTSLCA2ALDH1A1CYP1A2
SCHEMBL4466486 0.83 ALDH1A1 (0.59) KMT2ATSHRCTSLCA2ALDH1A1
SCHEMBL4466483 0.83 ALDH1A1 (0.59) KMT2ATSHRCTSLCA2ALDH1A1
SCHEMBL4474731 0.83 ALDH1A1 (0.59) KMT2ATSHRCTSLCA2ALDH1A1
SCHEMBL4460359 0.83 CTSL (0.57) NPC1FPR2KMT2ATSHRCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090042260-A1 PROCESS FOR PREPARING OPTICALLY ACTIVE (S OR R)-ALPHA-AMINO ACID AND OPTICALLY ACTIVE (R OR S)-ALPHA-AMINO ACID ESTER UBE INDUSTRIES, LTD. (JP) 2009-02-12 US disclosed
EP-1942193-A1 PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE (S OR R)-a-AMINO ACID OR OPTICALLY ACTIVE (S OR R)-a -AMINO ACID ESTER Ube Industries, Ltd. (JP) 2008-07-09 EP disclosed