Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | AGXT | P21549 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456076 | 0.83 | ALDH1A1 (0.38) | TAAR1IDO1AGXTMPO | |
| SCHEMBL1172013 | 0.74 | BACE1 (0.42) | — | |
| SCHEMBL3685171 | 0.71 | PARP1 (0.41) | TAAR1IDO1AGXTMEN1KMT2A | |
| SCHEMBL3163183 | 0.69 | TAAR1 (0.54) | TAAR1IDO1AGXTAOC3AKT2 | |
| SCHEMBL12952359 | 0.67 | AKT2 (0.52) | TAAR1IDO1AGXTMEN1KMT2A | |
| SCHEMBL1172247 | 0.65 | ALDH1A1 (0.41) | TAAR1IDO1MEN1KMT2ADHFR | |
| SCHEMBL29947713 | 0.64 | TAAR1 (0.71) | TAAR1IDO1AGXTAOC3MAOB | |
| SCHEMBL96112 | 0.64 | TAAR1 (0.60) | TAAR1IDO1AGXTAOC3MAOB | |
| SCHEMBL42954 | 0.64 | TAAR1 (0.71) | TAAR1IDO1AGXTAOC3MAOB | |
| SCHEMBL4551035 | 0.64 | TAAR1 (0.60) | TAAR1IDO1AGXTAOC3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | disclosed |