Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.54 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.54 |
| ▸ | GCGR | P47871 | 11/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.53 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | FRK | P42685 | 2/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4473119 | 0.81 | MAPK14 (0.65) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6107665 | 0.80 | MAPK14 (0.54) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1387734 | 0.79 | MAPK14 (0.67) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL9646788 | 0.79 | MAPK14 (0.67) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4460361 | 0.76 | MAPK14 (0.51) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8486608 | 0.76 | MAPK14 (0.62) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4563107 | 0.76 | ALOX5 (1.00) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8113784 | 0.75 | MAPK14 (0.60) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6601709 | 0.75 | MAPK14 (0.60) | ALOX5MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5435972 | 0.74 | KDM4E (0.48) | ALOX5MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582660-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | C-A-I-R BIOSCIENCES GMBH (DE) | 2009-09-01 | — | — | US | disclosed |
| US-20060235054-A1 | 2-Thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE-GMBH (DE) | 2006-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235054-A1 | 2-Thio-substituted imidazole derivatives and their use in pharmaceutics | IL2, TPMT, IFNG | ALOX5 1110/4885MAPK14 3841/4885MAPK13 3803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.