Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | LAP3 | P28838 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13919525 | 1.00 | POLB (0.76) | POLBALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL4481252 | 0.90 | ALDH1A1 (0.74) | POLBALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL13919544 | 0.90 | ALDH1A1 (0.74) | POLBALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL6307483 | 0.87 | POLB (0.60) | POLBALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL6307495 | 0.87 | POLB (0.60) | POLBALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL5506018 | 0.87 | ALDH1A1 (1.00) | POLBALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL4800642 | 0.87 | ALDH1A1 (1.00) | POLBALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL4797064 | 0.87 | ALDH1A1 (1.00) | POLBALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL6690653 | 0.83 | ALDH1A1 (0.81) | POLBALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL4463330 | 0.81 | KMT2A (0.55) | POLBALDH1A1L3MBTL1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931657-B1 | NOVEL HIGH AFFINITY QUINOLINE-BASED KINASE LIGANDS | MERCK SHARP & DOHME (US) | 2013-12-25 | — | — | EP | disclosed |
| US-7511063-B2 | High affinity quinoline-based kinase ligands | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| CN-101287727-A | Novel high affinity quinoline-based kinase ligands | SCHERING CORP (US) | 2008-10-15 | — | — | CN | disclosed |
| US-20080045568-A1 | Novel high affinity quinoline-based kinase ligands | SCHERING CORPORATION | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045568-A1 | Novel high affinity quinoline-based kinase ligands | CDKL2, CDK2, CDKL1 | POLB 710/4885ALDH1A1 4640/4885L3MBTL1 2552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.