Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 3/20 | 0.55 |
| ▸ | PPARA | Q07869 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PPARD | Q03181 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13919544 | 1.00 | ALDH1A1 (0.74) | ALDH1A1GAAPOLBKMT2AAADAT | |
| SCHEMBL13919525 | 0.90 | POLB (0.76) | ALDH1A1GAAPOLBKMT2AL3MBTL1 | |
| SCHEMBL4467004 | 0.90 | POLB (0.76) | ALDH1A1GAAPOLBKMT2AL3MBTL1 | |
| SCHEMBL7697972 | 0.87 | POLB (0.73) | ALDH1A1GAAPOLBKMT2AAADAT | |
| SCHEMBL392680 | 0.86 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBKMT2AAADAT | |
| SCHEMBL4861809 | 0.86 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBKMT2AAADAT | |
| SCHEMBL30216480 | 0.86 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBKMT2AAADAT | |
| SCHEMBL478614 | 0.86 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBKMT2AAADAT | |
| Hydrochloric Acid SCHEMBL7840775 | 0.85 | ALDH1A1 (0.97) | ALDH1A1GAAPOLBKMT2AAADAT | |
| SCHEMBL18262723 | 0.84 | KMT2A (0.77) | ALDH1A1GAAPOLBKMT2AAADAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931657-B1 | NOVEL HIGH AFFINITY QUINOLINE-BASED KINASE LIGANDS | MERCK SHARP & DOHME (US) | 2013-12-25 | — | — | EP | disclosed |
| US-7511063-B2 | High affinity quinoline-based kinase ligands | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| EP-1931657-A2 | NOVEL HIGH AFFINITY QUINOLINE-BASED KINASE LIGANDS | SCHERING CORPORATION (US) | 2008-06-18 | — | — | EP | disclosed |
| US-20080045568-A1 | Novel high affinity quinoline-based kinase ligands | SCHERING CORPORATION | 2008-02-21 | — | — | US | disclosed |
| WO-2007022241-A2 | NOVEL HIGH AFFINITY QUINOLINE-BASED KINASE LIGANDS | SCHERING CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045568-A1 | Novel high affinity quinoline-based kinase ligands | CDKL2, CDK2, CDKL1 | ALDH1A1 4640/4885GAA 2157/4885POLB 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.