Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4463538 | 0.96 | CNR1 (0.30) | CNR1 | |
| Hydrochloric Acid SCHEMBL4460800 | 0.92 | ALDH1A1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL4474485 | 0.87 | ALDH1A1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL4482602 | 0.83 | DHFR (0.34) | CNR1DRD2SLC6A2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL5689190 | 0.82 | SLC6A4 (0.33) | CNR1DRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL2522861 | 0.81 | ALDH1A1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL4460785 | 0.80 | CNR1 (0.34) | CNR1 | |
| Hydrochloric Acid SCHEMBL4461205 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL4465423 | 0.79 | SLC6A2 (0.35) | MAPTDRD2SLC6A2HTR2AHTR2C | |
| SCHEMBL27514160 | 0.79 | CNR1 (0.37) | CNR1MAPTDRD2SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569651-B2 | Transition metal compound, ligand system, catalyst system and its use for the polymerization and copolymerization of olefins | BASELL POLYPROPYLEN GMBH (DE) | 2009-08-04 | — | — | US | disclosed |
| US-7342078-B2 | Transition metal compound, ligand system, catalyst system and the use of the latter for polymerisation and copolymerisation of olefins | BASELL POLYOLEFINE GMBH (DE) | 2008-03-11 | — | — | US | disclosed |
| US-20060020096-A1 | Transition metal compound, ligand system, catalyst system and its use for the polymerization and copolymerization of olefins | SCHOTTEK JORG | 2006-01-26 | — | — | US | disclosed |