⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215870 | 0.81 | KDM1A (0.44) | — | |
| Bromide SCHEMBL4474316 | 0.80 | KDM1A (0.43) | — | |
| SCHEMBL4463819 | 0.79 | HSD11B1 (0.38) | — | |
| SCHEMBL5220054 | 0.79 | HCRTR1 (0.31) | — | |
| SCHEMBL4463636 | 0.79 | — | — | |
| Bromide SCHEMBL4466117 | 0.78 | HSD11B1 (0.37) | — | |
| Bromide SCHEMBL4469354 | 0.78 | HCRTR1 (0.31) | — | |
| SCHEMBL4467652 | 0.78 | KDM1A (0.43) | — | |
| SCHEMBL5217300 | 0.78 | HPGDS (0.37) | — | |
| SCHEMBL4463632 | 0.77 | CYP11B1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585974-B2 | Derivatives of 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, their preparation and their therapeutic application | SANOFI-AVENTIS (FR) | 2009-09-08 | — | — | US | claimed |
| US-20070185137-A1 | Derivatives of 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, their preparation and their therapeutic application | SANOFI-AVENTIS (FR) | 2007-08-09 | — | — | US | claimed |
| EP-1465893-B1 | DERIVATIVES OF 5-(PYRIDIN-3-YL)-1-AZABICYCLO (3.2.1) OCTANE, THE PREPARATION THEREOF AND THE APPLICATION OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2007-02-28 | — | — | EP | claimed |