Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | BRS3 | P32247 | 16/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25196759 | 0.85 | KDM4E (0.58) | KDM4EALDH1A1HIF1AHPGDNPSR1 | |
| SCHEMBL5999840 | 0.82 | KMT2A (0.56) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL183618 | 0.80 | P2RX7 (0.53) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL19827118 | 0.80 | CYP3A4 (0.56) | KDM4EALDH1A1HPGDNPSR1LMNA | |
| Hydrochloric Acid SCHEMBL6298078 | 0.79 | P2RX7 (0.52) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL2343194 | 0.77 | ALDH1A1 (0.47) | KDM4EALDH1A1HIF1AHPGDNPSR1 | |
| SCHEMBL18835432 | 0.76 | C5AR1 (0.57) | KDM4EALDH1A1HIF1AHPGDNPSR1 | |
| SCHEMBL20589776 | 0.76 | C5AR1 (0.63) | KDM4EALDH1A1HIF1AHPGDNPSR1 | |
| SCHEMBL31095479 | 0.76 | C5AR1 (0.63) | KDM4EALDH1A1HIF1AHPGDNPSR1 | |
| SCHEMBL1831098 | 0.75 | BRS3 (0.57) | KDM4EALDH1A1HIF1AHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7494992-B2 | Antiparasitic terpene alkaloids | PFIZER INC. (US) | 2009-02-24 | — | — | US | disclosed |
| US-20070185101-A1 | Antiparasitic terpene alkaloids | PFIZER PRODUCTS INC | 2007-08-09 | — | — | US | disclosed |
| EP-1597264-A2 | ANTIPARASITIC TERPENE ALKALOIDS | Pfizer Limited (GB) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004072086-A2 | ANTIPARASITIC TERPENE ALKALOIDS | PFIZER LIMITED (GB) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185101-A1 | Antiparasitic terpene alkaloids | CYP51A1, DHPS, CYP8B1 | KDM4E 752/4885ALDH1A1 441/4885HIF1A 3497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.