⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464426 | 0.70 | NPC1 (0.38) | — | |
| SCHEMBL4467811 | 0.70 | ALDH1A1 (0.40) | — | |
| SCHEMBL4482479 | 0.69 | CYP2D6 (0.33) | — | |
| SCHEMBL4474004 | 0.69 | RAB9A (0.41) | — | |
| SCHEMBL4462865 | 0.68 | ALDH1A1 (0.32) | — | |
| SCHEMBL4467332 | 0.58 | ALDH1A1 (0.34) | — | |
| SCHEMBL4473362 | 0.56 | — | — | |
| SCHEMBL4473864 | 0.55 | HSD17B10 (0.38) | — | |
| SCHEMBL4472455 | 0.55 | SPR (0.34) | — | |
| SCHEMBL4467896 | 0.54 | KCNJ1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576094-B2 | Spiro derivatives as lipoxygenase inhibitors | ELI LILLY AND COMPANY (US) | 2009-08-18 | — | — | US | disclosed |
| US-20060128790-A1 | Spiro derivatives as lipoxygenase inhibitors | GALILEO PHARMACEUTICALS, INC. | 2006-06-15 | — | — | US | disclosed |