SCHEMBL446991

SCHEMBL446991

CCCCCCCCCCCCCCCCCCCCCCCCC=CCCCCCCCC(N)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FAAH O00519 4/20 1.00
▸ SOAT1 P35610 2/20 1.00
▸ CYP1A2 P05177 2/20 1.00
▸ CYP2C19 P33261 2/20 1.00
▸ KMT2A Q03164 2/20 1.00
▸ MEN1 O00255 1/20 1.00
▸ TP53 P04637 1/20 1.00
▸ CYP3A4 P08684 1/20 1.00
▸ KDM4E B2RXH2 2/20 0.89
▸ CNR1 P21554 1/20 0.78
▸ TERT O14746 3/20 0.70
▸ PTPN1 P18031 3/20 0.70
▸ PPARG P37231 3/20 0.70
▸ PPARD Q03181 3/20 0.70
▸ PPARA Q07869 3/20 0.70
▸ MAPT P10636 2/20 0.70
▸ BLM P54132 2/20 0.70
▸ HSD17B10 Q99714 2/20 0.70
▸ FABP4 P15090 2/20 0.70
▸ GMNN O75496 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oleamide SCHEMBL7650473 1.00 FAAH (1.00) FAAHSOAT1CYP1A2CYP2C19KMT2A
SCHEMBL11846101 1.00 FAAH (1.00) FAAHSOAT1CYP1A2CYP2C19KMT2A
Oleamide SCHEMBL195221 1.00 FAAH (1.00) FAAHSOAT1CYP1A2CYP2C19KMT2A
SCHEMBL21983255 1.00 FAAH (1.00) FAAHSOAT1CYP1A2CYP2C19KMT2A
SCHEMBL23528231 1.00 FAAH (1.00) FAAHSOAT1CYP1A2CYP2C19KMT2A
SCHEMBL10445392 1.00 FAAH (1.00) FAAHSOAT1CYP1A2CYP2C19KMT2A
SCHEMBL24340776 1.00 FAAH (1.00) FAAHSOAT1CYP1A2CYP2C19KMT2A
SCHEMBL21501560 1.00 FAAH (1.00) FAAHSOAT1CYP1A2CYP2C19KMT2A
SCHEMBL21654359 1.00 FAAH (1.00) FAAHSOAT1CYP1A2CYP2C19KMT2A
SCHEMBL22419041 1.00 FAAH (1.00) FAAHSOAT1CYP1A2CYP2C19KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1771206-B1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS GMBH (DE) 2018-04-11 — — EP disclosed
US-20170036990-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2017-02-09 — — US disclosed
US-9486538-B2 Lipids, lipid complexes and use thereof SILENCE THERAPEUTICS GMBH (DE) 2016-11-08 — — US disclosed
US-9387262-B2 Coated lipid complexes and their use SILENCE THERAPEUTICS GMBH (DE) 2016-07-12 — — US disclosed
EP-2992902-A1 LIPID COMPLEXES COATED WITH PEG AND THEIR USES Silence Therapeutics GmbH (DE) 2016-03-09 — — EP disclosed
CN-102940891-B Lipid, lipid complex and application thereof SILENCE THERAPEUTICS AG (DE) 2016-02-24 — — CN disclosed
US-20150359906-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2015-12-17 — — US disclosed
US-9125820-B2 Lipids, lipid complexes and use thereof SILENCE THERAPEUTICS GMBH (DE) 2015-09-08 — — US disclosed
EP-1830888-B1 LIPID COMPLEXES COATED WITH PEG AND THEIR USE SILENCE THERAPEUTICS GMBH (DE) 2015-08-05 — — EP disclosed
US-20150031752-A1 COATED LIPID COMPLEXES AND THEIR USE SILENCE THERAPEUTICS AG (DE) 2015-01-29 — — US disclosed
US-20120065138-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2012-03-15 — — US disclosed
US-20110294871-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2011-12-01 — — US disclosed
US-8017804-B2 Lipids, lipid complexes and use thereof SILENCE THERAPEUTICS AG (DE) 2011-09-13 — — US disclosed
US-20100062967-A1 COATED LIPID COMPLEXES AND THEIR USE SILENCE THERAPEUTICS AG (DE) 2010-03-11 — — US disclosed
WO-2006069782-A9 LIPID COMPLEXES COATED WITH PEG AND THEIR USE SILENCE THERAPEUTICS AG (DE) 2009-04-30 — — WO disclosed
US-20080274116-A1 Lipids, Lipid Complexes and Use Thereof SILENCE THERAPEUTICS AG (DE) 2008-11-06 — — US disclosed
EP-1830888-A2 LIPID COMPLEXES COATED WITH PEG AND THEIR USE Silence Therapeutics AG (DE) 2007-09-12 — — EP disclosed
EP-1771206-A2 LIPIDS, LIPID COMPLEXES AND USE THEREOF atugen AG (DE) 2007-04-11 — — EP disclosed
WO-2006069782-A2 LIPID COMPLEXES COATED WITH PEG AND THEIR USE SILENCE THERAPEUTICS AG. (DE) 2006-07-06 — — WO disclosed
WO-2005105152-A2 LIPIDS, LIPID COMPLEXES AND USE THEREOF ATUGEN AG (DE) 2005-11-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120065138-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, SGMS1 FAAH 167/4885SOAT1 82/4885CYP1A2 856/4885
US-20110294871-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, SGMS1 FAAH 167/4885SOAT1 82/4885CYP1A2 856/4885
US-20100062967-A1 COATED LIPID COMPLEXES AND THEIR USE HDLBP, NR1H3, CETP FAAH 313/4885SOAT1 63/4885CYP1A2 2920/4885
US-20170036990-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, LIPC FAAH 185/4885SOAT1 107/4885CYP1A2 718/4885
US-20150359906-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, LIPC FAAH 185/4885SOAT1 107/4885CYP1A2 718/4885
US-20150031752-A1 COATED LIPID COMPLEXES AND THEIR USE HDLBP, NR1H3, CETP FAAH 313/4885SOAT1 63/4885CYP1A2 2920/4885
US-20080274116-A1 Lipids, Lipid Complexes and Use Thereof MGLL, LIPA, SGMS1 FAAH 153/4885SOAT1 79/4885CYP1A2 771/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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